Rociclovir

Rociclovir

SCHEMBL1228859

CC(C)OCC(COC(C)C)OCn1cnc2cnc(N)nc21

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.49
KDM4E B2RXH2 1/20 0.49
HPGD P15428 1/20 0.49
ADRA1A P35348 1/20 0.49
HSD17B10 Q99714 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
HSP90AA1 P07900 2/20 0.43
HSP90AB1 P08238 2/20 0.43
HDAC6 Q9UBN7 2/20 0.42
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.36
NFKB1 P19838 1/20 0.36
BLM P54132 1/20 0.36
VCP P55072 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HIF1A Q16665 1/20 0.36
PDE3A Q14432 1/20 0.35
IRAK4 Q9NWZ3 5/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rociclovir SCHEMBL29573658 1.00 ALDH1A1 (0.49) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL9827211 0.90 ALDH1A1 (0.62) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL9575793 0.87 ALDH1A1 (0.40) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL10645986 0.83 ALDH1A1 (0.69) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL9575400 0.83 KDM4E (0.46) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL10996224 0.83 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL9584417 0.83 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL10817909 0.82 ALDH1A1 (0.55) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL9575559 0.80 ALDH1A1 (0.41) ALDH1A1KDM4EHPGDADRA1AHSD17B10
SCHEMBL9583133 0.80 ALDH1A1 (0.53) ALDH1A1KDM4EHPGDADRA1AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-0948332-B1 ANTIHERPETIC MEDICATED STICK CONTAINING ACYCLOVIR FOR TOPICAL APPLICATION RECORDATI CHEM PHARM (CH) 2003-09-03 EP claimed
EP-0618226-B1 Inhibitors of herpes viral ribonculeotide reductase BOEHRINGER INGELHEIM CA LTD (CA) 2000-11-29 EP claimed
EP-0948332-A1 ANTIHERPETIC PHARMACEUTICAL COMPOSITIONS CONTAINING ACYCLOVIR FOR TOPICAL APPLICATORS RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) 1999-10-13 EP claimed
EP-0560267-B1 Isosteric antiherpes peptide derivatives BOEHRINGER INGELHEIM CA LTD (CA) 1998-08-19 EP claimed
CN-1118601-A Inhibitors of herpes viral ribonucleotide reductase BIO MEGA BOEHRINGER INGELHEIM (CA) 1996-03-13 CN claimed
US-5380727-A Antiviral nucleoside analog and a ribonucleotide reductase inhibiting peptide derivative BIO-MEGA, INC. (CA) 1995-01-10 US claimed
WO-1994025046-A1 METHOD OF COMBATING ACYCLOVIR-RESISTANT HERPES SIMPLEX VIRAL INFECTIONS BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-11-10 WO claimed
EP-0618226-A1 Inhibitors of herpes viral ribonculeotide reductase BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-10-05 EP claimed
WO-1994020528-A1 INHIBITORS OF HERPES VIRAL RIBONUCLEOTIDE REDUCTASE BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1994-09-15 WO claimed
WO-1993018056-A1 ISOSTERIC ANTIHERPES PEPTIDE DERIVATIVES BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1993-09-16 WO claimed
EP-0560274-A1 Antiherpes peptide derivatives having a ureido N-terminus BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1993-09-15 EP claimed
EP-0560267-A1 Isosteric antiherpes peptide derivatives BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1993-09-15 EP claimed
EP-0493767-A2 Synergistic combination for treating herpes infections BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1992-07-08 EP claimed
EP-0493770-A2 Antiherpes compositions BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1992-07-08 EP claimed