Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 18/20 | 0.48 |
| ▸ | TDO2 | P48775 | 13/20 | 0.44 |
| ▸ | IDO2 | Q6ZQW0 | 9/20 | 0.44 |
| ▸ | APAF1 | O14727 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29921856 | 1.00 | IDO1 (0.48) | IDO1TDO2IDO2APAF1NPC1 | |
| SCHEMBL12325627 | 0.80 | IDO1 (0.57) | IDO1TDO2IDO2APAF1NPC1 | |
| SCHEMBL12290211 | 0.78 | IDO1 (0.57) | IDO1TDO2IDO2APAF1NPC1 | |
| SCHEMBL12289968 | 0.74 | IDO1 (0.71) | IDO1TDO2IDO2APAF1NPC1 | |
| SCHEMBL9103697 | 0.71 | TDO2 (0.58) | IDO1TDO2IDO2APAF1NPC1 | |
| SCHEMBL14492731 | 0.69 | IDO1 (0.76) | IDO1TDO2IDO2APAF1NPC1 | |
| SCHEMBL29383491 | 0.69 | IDO1 (0.53) | IDO1TDO2IDO2APAF1NPC1 | |
| SCHEMBL12290014 | 0.67 | APAF1 (0.59) | IDO1TDO2IDO2APAF1NPC1 | |
| SCHEMBL31382839 | 0.63 | IDO1 (0.73) | IDO1TDO2IDO2APAF1NPC1 | |
| SCHEMBL24919973 | 0.63 | MAPT (0.44) | NPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012987-B2 | Indolo[2,1-b] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2011-09-06 | — | — | US | disclosed |