Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.50 |
| ▸ | P4HB | P07237 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL386761 | 0.98 | P4HB (0.49) | ESR1ESR2P4HBKMT2AGRIN2D | |
| SCHEMBL18594867 | 0.98 | P4HB (0.49) | ESR1ESR2P4HBKMT2AGRIN2D | |
| SCHEMBL16902819 | 0.91 | GRIN2B (0.49) | ESR1ESR2GRIN2DGRIN3BADRA1D | |
| SCHEMBL14734507 | 0.91 | GRIN2B (0.49) | ESR1ESR2GRIN2DGRIN3BADRA1D | |
| SCHEMBL20727175 | 0.83 | ESR2 (0.50) | ESR1ESR2GRIN2DGRIN3BADRA1D | |
| SCHEMBL2948678 | 0.81 | GBA1 (0.66) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL10546238 | 0.81 | GRIN2B (0.43) | ESR1ESR2GRIN2DGRIN3BADRA1D | |
| SCHEMBL4364820 | 0.79 | ESR2 (0.53) | ESR1ESR2GRIN2DGRIN3BADRA1D | |
| Hydrochloric Acid SCHEMBL1006327 | 0.79 | GBA1 (0.63) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL9748441 | 0.79 | EED (0.51) | P4HBKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560956-B1 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | OCTETA THERAPEUTICS LLC (US) | 2016-10-26 | — | — | EP | disclosed |
| US-8937182-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2015-01-20 | — | — | US | disclosed |
| US-8937182-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2015-01-20 | — | — | US | disclosed |
| US-20130204004-A1 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130204004-A1 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2013-08-08 | — | — | US | disclosed |
| WO-2011133442-A1 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) | 2011-10-27 | — | — | WO | disclosed |
| CN-101045787-A | Urethane polymer having bisphenol group and photoimageable composition containing the same | CHANGXING CHEMICAL INDUSTRY CO (CN) | 2007-10-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130204004-A1 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | PPARG, PPARD, PPARA | ESR1 1442/4885ESR2 578/4885P4HB 1653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.