Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 15/20 | 0.59 |
| ▸ | CDK2 | P24941 | 15/20 | 0.59 |
| ▸ | CCNE2 | O96020 | 14/20 | 0.59 |
| ▸ | CDK1 | P06493 | 8/20 | 0.59 |
| ▸ | CDK4 | P11802 | 8/20 | 0.59 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.59 |
| ▸ | CCND1 | P24385 | 7/20 | 0.59 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.59 |
| ▸ | CCND3 | P30281 | 4/20 | 0.42 |
| ▸ | CCND2 | P30279 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466 | 0.89 | CCNE2 (0.58) | CCNE1CDK2CCNE2CDK1CDK4 | |
| SCHEMBL31206542 | 0.77 | CDK2 (0.52) | CCNE1CDK2CCNE2CDK1CDK4 | |
| SCHEMBL21963005 | 0.76 | CCNE2 (0.44) | CCNE1CDK2CCNE2CDK1CDK4 | |
| SCHEMBL14095608 | 0.76 | ALDH1A1 (0.53) | CCNE1CDK2CCNE2CDK1CDK4 | |
| SCHEMBL16724117 | 0.76 | CCNE1 (0.44) | CCNE1CDK2CCNE2CDK1CDK4 | |
| SCHEMBL21963023 | 0.75 | CCNE2 (0.44) | CCNE1CDK2CCNE2CDK1CDK4 | |
| SCHEMBL1261556 | 0.74 | CDK2 (0.47) | CCNE1CDK2CCNE2CDK1CDK4 | |
| SCHEMBL5216993 | 0.74 | CCNE1 (1.00) | CCNE1CDK2CCNE2CDK1CDK4 | |
| SCHEMBL16724105 | 0.74 | SMN1; SMN2 (0.41) | CCNE1CDK2CCNE2CDK1CDK4 | |
| SCHEMBL16086926 | 0.74 | CDK2 (0.49) | CCNE1CDK2CCNE2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| US-9133218-B2 | Pesticidally active pyridyl- and pyrimidyl-substituted thiazole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2015-09-15 | — | — | US | disclosed |
| US-9133218-B2 | Pesticidally active pyridyl- and pyrimidyl-substituted thiazole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2015-09-15 | — | — | US | disclosed |
| US-9073940-B2 | Tricyclic pyrazol amine derivatives | MERCK SERONO SA (CH) | 2015-07-07 | — | — | US | disclosed |
| US-9073940-B2 | Tricyclic pyrazol amine derivatives | MERCK SERONO SA (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20150141423-A1 | PESTICIDALLY ACTIVE PYRIDYL- AND PYRIMIDYL- SUBSTITUTED THIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-05-21 | — | — | US | disclosed |
| US-20150141423-A1 | PESTICIDALLY ACTIVE PYRIDYL- AND PYRIMIDYL- SUBSTITUTED THIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-05-21 | — | — | US | disclosed |
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | PI4KB, MTOR, PI4KA | CCNE1 1483/4885CDK2 160/4885CCNE2 1986/4885 |
| US-20150141423-A1 | PESTICIDALLY ACTIVE PYRIDYL- AND PYRIMIDYL- SUBSTITUTED THIAZOLE DERIVATIVES | PLPBP, DDT, PIR | CCNE1 2973/4885CDK2 401/4885CCNE2 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.