Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 10/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | CDK4 | P11802 | 4/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.49 |
| ▸ | CCND1 | P24385 | 4/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | CCND2 | P30279 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16724105 | 0.85 | SMN1; SMN2 (0.41) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL999731 | 0.82 | SMN1; SMN2 (0.56) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2667029 | 0.82 | CDK2 (0.45) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL9072653 | 0.78 | APEX1 (0.47) | CDK2CCNE2CCNE1SMN1; SMN2MYC | |
| SCHEMBL16086613 | 0.75 | SMN1; SMN2 (0.53) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL12292 | 0.74 | CCNE1 (0.59) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2656865 | 0.73 | CDK2 (0.49) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL738352 | 0.71 | CDK2 (0.48) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL640218 | 0.71 | MYC (0.47) | CDK2CCNE2CCNE1SMN1; SMN2MYC | |
| SCHEMBL688576 | 0.70 | CCNB2 (0.64) | CDK2CCNE2CCNE1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921576-B2 | Spiroindoline compound, and medicinal agent comprising same | KOWA COMPANY, LTD. (JP) | 2014-12-30 | — | — | US | disclosed |
| US-20140309207-A1 | NOVEL SPIROINDOLINE COMPOUND, AND MEDICINAL AGENT COMPRISING SAME | KOWA COMPANY, LTD (JP) | 2014-10-16 | — | — | US | disclosed |
| EP-2781521-A1 | NOVEL SPIROINDOLINE COMPOUND, AND MEDICINAL AGENT COMPRISING SAME | Kowa Company, Ltd. (JP) | 2014-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309207-A1 | NOVEL SPIROINDOLINE COMPOUND, AND MEDICINAL AGENT COMPRISING SAME | GCKR, GCK, GALK1 | CDK2 552/4885CCNE2 1668/4885CCNE1 1437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.