Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GRN | P28799 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31661910 | 0.84 | TLR2 (0.55) | FOLH1ALDH1A1LMNAMMP2TLR2 | |
| SCHEMBL894883 | 0.83 | FOLH1 (0.49) | FOLH1ALDH1A1LMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL895695 | 0.82 | FOLH1 (0.48) | FOLH1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL10420541 | 0.82 | PPARG (0.49) | FOLH1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL6566486 | 0.81 | FOLH1 (0.61) | FOLH1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1096205 | 0.79 | ALDH1A1 (0.51) | FOLH1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL28805317 | 0.79 | ALDH1A1 (0.51) | FOLH1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL11361690 | 0.78 | PPARG (0.52) | ALDH1A1LMNAMEN1KMT2ACYP2C19 | |
| SCHEMBL8003721 | 0.77 | ALDH1A1 (0.54) | FOLH1ALDH1A1LMNAGRNSORT1 | |
| SCHEMBL29213433 | 0.77 | GRN (0.52) | FOLH1ALDH1A1LMNAGRNSORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2011133653-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS, INCORPORATED (US) | 2011-10-27 | — | — | WO | disclosed |