Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8039590 | 0.91 | HTT (0.52) | HTTLMNASMN1; SMN2PLAUKEAP1 | |
| SCHEMBL7355388 | 0.91 | HTT (0.57) | HTTLMNASMN1; SMN2CA12CA1 | |
| SCHEMBL13622435 | 0.88 | LMNA (0.49) | HTTLMNASMN1; SMN2PLAUCA12 | |
| SCHEMBL12295603 | 0.88 | PLAU (0.47) | HTTLMNASMN1; SMN2PLAUCA12 | |
| SCHEMBL989685 | 0.87 | TGM2 (0.55) | HTTLMNASMN1; SMN2KMT2AKEAP1 | |
| SCHEMBL5097623 | 0.86 | LMNA (0.50) | HTTLMNASMN1; SMN2CA12CA1 | |
| SCHEMBL7359305 | 0.86 | HTT (0.69) | HTTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7358569 | 0.86 | LMNA (0.49) | HTTLMNASMN1; SMN2PLAUCA12 | |
| SCHEMBL14598314 | 0.85 | HTT (0.64) | HTTLMNASMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL13622431 | 0.85 | HTT (0.50) | HTTLMNASMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011104649-A1 | PEPTIDE ANALOGUES | PFIZER LIMITED (GB) | 2011-09-01 | — | — | WO | disclosed |