Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11723871 | 0.84 | HTT (0.47) | HTTSMN1; SMN2GAANCOA1NCOA3 | |
| SCHEMBL12672297 | 0.81 | HTT (0.45) | HTTSMN1; SMN2GAANCOA1NCOA3 | |
| SCHEMBL11724081 | 0.81 | ALDH1A1 (0.52) | HTTSMN1; SMN2GAANCOA1NCOA3 | |
| SCHEMBL11722567 | 0.81 | HTT (0.44) | HTTSMN1; SMN2GAANCOA1NCOA3 | |
| SCHEMBL2747914 | 0.81 | ALDH1A1 (0.57) | HTTSMN1; SMN2GAANCOA1NCOA3 | |
| SCHEMBL1231890 | 0.80 | KDM4C (0.52) | HTTSMN1; SMN2GAANCOA1NCOA3 | |
| SCHEMBL4444121 | 0.80 | KDM4C (0.52) | HTTSMN1; SMN2GAANCOA1NCOA3 | |
| SCHEMBL7455764 | 0.79 | HTT (0.48) | HTTSMN1; SMN2GAANCOA1NCOA3 | |
| SCHEMBL11721147 | 0.79 | HTT (0.45) | HTTSMN1; SMN2GAANCOA1NCOA3 | |
| SCHEMBL11725945 | 0.79 | LMNA (0.49) | HTTSMN1; SMN2GAANCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580439-B2 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-02-28 | — | — | US | disclosed |
| EP-2727909-A1 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-05-07 | — | — | EP | disclosed |
| EP-2134689-B1 | INHIBITORS OF FOCAL ADHESION KINASE | SCRIPPS RESEARCH INST (US) | 2014-04-23 | — | — | EP | disclosed |
| CN-103588704-A | Inhibitors of focal adhesion kinase | SCRIPPS RESEARCH INST | 2014-02-19 | — | — | CN | disclosed |
| US-20130281443-A1 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-10-24 | — | — | US | disclosed |
| US-8501763-B2 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-08-06 | — | — | US | disclosed |
| CN-102666540-A | Fused azine derivatives for the treatment of acetylcholine receptor related diseases | MSD OSS BV | 2012-09-12 | — | — | CN | disclosed |
| US-20110046121-A1 | INHIBITORS OF FOCAL ADHESION KINASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-02-24 | — | — | US | disclosed |
| CN-101679264-A | inhibitors of focal adhesion kinase | SCRIPPS RESEARCH INST | 2010-03-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046121-A1 | INHIBITORS OF FOCAL ADHESION KINASE | PTK2, CABLES1, TNK2 | HTT 4542/4885SMN1; SMN2 2953/4885GAA 3211/4885 |
| US-20130281443-A1 | INHIBITORS OF FOCAL ADHESION KINASE | PTK2, CABLES1, TNK2 | HTT 4542/4885SMN1; SMN2 2953/4885GAA 3211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.