Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241840 | 0.78 | RAB9A (0.35) | NPC1RAB9AMAPT | |
| SCHEMBL13424020 | 0.68 | HDAC6 (0.55) | NPC1RAB9AMAPT | |
| SCHEMBL12299447 | 0.68 | CYP19A1 (0.43) | NPC1RAB9AMAPT | |
| SCHEMBL9597537 | 0.67 | ALOX15 (0.35) | NPC1RAB9AMAPT | |
| SCHEMBL5553168 | 0.67 | RAB9A (0.65) | NPC1RAB9AMAPT | |
| SCHEMBL12299450 | 0.67 | TP53 (0.50) | NPC1RAB9AMAPT | |
| SCHEMBL23585284 | 0.67 | NPC1 (0.34) | NPC1RAB9AMAPT | |
| SCHEMBL13424022 | 0.64 | HDAC6 (0.39) | NPC1RAB9AMAPT | |
| SCHEMBL5325733 | 0.64 | IDO1 (0.47) | NPC1RAB9AMAPT | |
| SCHEMBL18634497 | 0.63 | KDM4E (0.33) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140080756-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5]NONANE DERIVATIVES | PFIZER INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-20110230461-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES | PFIZER INC. | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080756-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5]NONANE DERIVATIVES | GIPR, GLP1R, GHSR | NPC1 1017/4885RAB9A 1048/4885MAPT 4349/4885 |
| US-20110230461-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES | GIPR, GLP1R, GHSR | NPC1 1028/4885RAB9A 1030/4885MAPT 4319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.