SCHEMBL12314904

CCOCCNC(=O)CCN(CCC(=O)NCCOCC)C(=O)CCC(=O)CCN(CCC(=O)NCC(=O)N(CCC(=O)NCCOCCOCC)CCC(=O)NCCOCCOCC(=O)N[C@H](C(=O)C[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCC(=N)N)C(=O)O)[C@H](C)O)C(=O)CNC(=O)CSC(C)=O

nearest known ligand 0.38

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	APLNR	P35414	1/20	0.38

▸	RAMP3	O60896	6/20	0.38

▸	CALCR	P30988	6/20	0.38

▸	GLP1R	P43220	13/20	0.38

▸	GIPR	P48546	13/20	0.38

▸	GCGR	P47871	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16351203	0.86	RAMP3 (0.48)	APLNRRAMP3CALCR
SCHEMBL16340628	0.81	APLNR (0.42)	APLNRRAMP3CALCRGLP1RGIPR
SCHEMBL16340730	0.77	RAMP3 (0.50)	APLNRRAMP3CALCR
SCHEMBL12337845	0.70	RAMP3 (0.46)	APLNRRAMP3CALCR
SCHEMBL12337799	0.69	RAMP3 (0.46)	APLNRRAMP3CALCR
SCHEMBL12339085	0.69	RAMP3 (0.46)	RAMP3CALCR
SCHEMBL16351204	0.69	RAMP3 (0.46)	RAMP3CALCR
SCHEMBL12314858	0.69	GRB2 (0.42)	APLNRRAMP3CALCR
SCHEMBL12237960	0.67	APLNR (0.37)	APLNRRAMP3CALCR
SCHEMBL12263597	0.66	APLNR (0.47)	APLNRRAMP3CALCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8263739-B2	also targeting tumor cells that express vascular endothelial growth factor neuropilin-1 receptor; radiotherapy; radiopharmaceuticals; treating angiogenesis	BRACCO SUISSE SA (CH)	2012-09-11	—	—	US	disclosed