Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573895 | 1.00 | CA2 (0.35) | CA2GAAGRIN2BLMNAALDH1A1 | |
| SCHEMBL3303040 | 1.00 | CA2 (0.35) | CA2GAAGRIN2BLMNAALDH1A1 | |
| SCHEMBL4329539 | 1.00 | CA2 (0.35) | CA2GAAGRIN2BLMNAALDH1A1 | |
| SCHEMBL3346701 | 1.00 | CA2 (0.35) | CA2GAAGRIN2BLMNAALDH1A1 | |
| SCHEMBL12315839 | 0.76 | CA2 (0.37) | CA2GAALMNAALDH1A1CA1 | |
| SCHEMBL6092290 | 0.76 | CA2 (0.37) | CA2GAALMNAALDH1A1CA1 | |
| SCHEMBL18651228 | 0.75 | CA2 (0.34) | CA2LMNACA1CA12CA3 | |
| SCHEMBL4196353 | 0.75 | CA2 (0.54) | CA2LMNACA1CA12CA3 | |
| SCHEMBL13852709 | 0.75 | CA2 (0.54) | CA2LMNACA1CA12CA3 | |
| SCHEMBL12315845 | 0.75 | CA2 (0.54) | CA2LMNACA1CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2683724-B1 | ASYMMETRIC REDUCTION PROCESS | ZACH SYSTEM SPA (IT) | 2015-05-06 | — | — | EP | disclosed |
| US-8927740-B2 | Asymmetric reduction process | ZACH SYSTEM S.P.A. (IT) | 2015-01-06 | — | — | US | disclosed |
| EP-2683724-A1 | ASYMMETRIC REDUCTION PROCESS | ZaCh System S.p.A. (IT) | 2014-01-15 | — | — | EP | disclosed |
| WO-2012120086-A1 | ASYMMETRIC REDUCTION PROCESS | ZACH SYSTEM S.P.A. (IT) | 2012-09-13 | — | — | WO | disclosed |
| US-8263787-B2 | Process for preparing dorzolamide | CIPLA LIMITED (IN) | 2012-09-11 | — | — | US | disclosed |
| US-8263787-B2 | Process for preparing dorzolamide | CIPLA LIMITED (IN) | 2012-09-11 | — | — | US | disclosed |
| WO-2011101704-A1 | PROCESS FOR PREPARING (4S, 6S)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO-[2,3-B]THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE AND ITS INTERMEDIATES | MICRO LABS LIMITED (IN) | 2011-08-25 | — | — | WO | disclosed |
| US-20100113804-A1 | Process for Preparing Dorzolamide | CIPLA LIMITED (IN) | 2010-05-06 | — | — | US | disclosed |
| US-20100113804-A1 | Process for Preparing Dorzolamide | CIPLA LIMITED (IN) | 2010-05-06 | — | — | US | disclosed |
| WO-2008135770-A2 | PROCESS FOR PREPARING DORZOLAM IDE | CIPLA LIMITED (IN) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113804-A1 | Process for Preparing Dorzolamide | SQOR, PPOX, DAO | CA2 605/4885GAA 2296/4885GRIN2B 2940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.