Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12314560 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPK1TSHRHSD11B1PTGES | |
| SCHEMBL3781020 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPK1TSHRHSD11B1PTGES | |
| SCHEMBL14551971 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPK1TSHRHSD11B1KMT2A | |
| SCHEMBL14551969 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPK1TSHRHSD11B1KMT2A | |
| SCHEMBL2898127 | 0.71 | HSD11B1 (0.52) | SMN1; SMN2MAPK1TSHRHSD11B1KMT2A | |
| SCHEMBL27934023 | 0.69 | MAPK1 (0.44) | SMN1; SMN2MAPK1TSHRHSD11B1KMT2A | |
| SCHEMBL12314563 | 0.69 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPK1TSHRHSD11B1ALDH1A1 | |
| SCHEMBL3359896 | 0.67 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPK1TSHRHSD11B1ALDH1A1 | |
| SCHEMBL3772574 | 0.67 | HSD11B1 (0.39) | SMN1; SMN2MAPK1TSHRHSD11B1KMT2A | |
| SCHEMBL14481601 | 0.67 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPK1TSHRHSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464635-B1 | COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES | SCRIPPS RESEARCH INST (US) | 2015-09-16 | — | — | EP | disclosed |
| US-8927736-B2 | Copper catalyzed cycloaddition of organic azides and 1-haloalkynes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-01-06 | — | — | US | disclosed |
| US-8927736-B2 | Copper catalyzed cycloaddition of organic azides and 1-haloalkynes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-01-06 | — | — | US | disclosed |
| US-8927736-B2 | Copper catalyzed cycloaddition of organic azides and 1-haloalkynes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-01-06 | — | — | US | disclosed |
| EP-2464635-A2 | COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES | The Scripps Research Institute (US) | 2012-06-20 | — | — | EP | disclosed |
| US-20120142935-A1 | COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-06-07 | — | — | US | disclosed |
| US-20120142935-A1 | COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-06-07 | — | — | US | disclosed |
| US-20120142935-A1 | COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-06-07 | — | — | US | disclosed |
| WO-2011019799-A2 | COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142935-A1 | COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES | AOC3, AOC2, CBR3 | SMN1; SMN2 4843/4885MAPK1 1440/4885TSHR 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.