Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1232285 | 0.71 | SMN1; SMN2 (0.50) | HSD11B1SMN1; SMN2MAPK1TSHRHTT | |
| SCHEMBL12314560 | 0.71 | SMN1; SMN2 (0.50) | HSD11B1SMN1; SMN2MAPK1TSHRHTT | |
| SCHEMBL1420611 | 0.70 | SMN1; SMN2 (0.52) | HSD11B1SMN1; SMN2MAPK1TSHRHSD17B10 | |
| SCHEMBL3781020 | 0.68 | SMN1; SMN2 (0.50) | HSD11B1SMN1; SMN2MAPK1TSHRHTT | |
| SCHEMBL14481601 | 0.67 | SMN1; SMN2 (0.42) | HSD11B1SMN1; SMN2MAPK1TSHRALDH1A1 | |
| SCHEMBL14481387 | 0.67 | SMN1; SMN2 (0.42) | HSD11B1SMN1; SMN2MAPK1TSHRALDH1A1 | |
| SCHEMBL27934023 | 0.66 | MAPK1 (0.44) | HSD11B1SMN1; SMN2MAPK1TSHRALDH1A1 | |
| SCHEMBL5326699 | 0.64 | PTGS1 (0.46) | TSHRHTTALDH1A1FLT3CYP3A4 | |
| SCHEMBL1336097 | 0.64 | CYP1A2 (0.45) | TSHRHTTALDH1A1FLT3CYP3A4 | |
| SCHEMBL8656275 | 0.64 | TSHR (0.49) | TSHRHTTALDH1A1FLT3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943004-B1 | RUTHENIUM-CATALYZED CYCLOADDITION OF ALKYNES AND ORGANIC AZIDES | SCRIPPS RESEARCH INST (US) | 2015-06-03 | — | — | EP | disclosed |
| US-8372986-B2 | Ruthenium-catalyzed cycloaddition of alkynes and organic azides | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-12 | — | — | US | disclosed |
| CN-101316640-B | Ruthenium-catalyzed cycloaddition of alkynes and organic azides | SCRIPPS RESEARCH INST | 2013-02-06 | — | — | CN | disclosed |
| US-20100286405-A1 | Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-11-11 | — | — | US | disclosed |
| CN-101316640-A | Ruthenium-catalyzed cycloaddition of alkynes and organic azides | SCRIPPS RESEARCH INST (US) | 2008-12-03 | — | — | CN | disclosed |
| EP-1943004-A2 | RUTHENIUM-CATALYZED CYCLOADDITION OF ALKYNES AND ORGANIC AZIDES | The Scripps Research Institute (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007041451-A2 | RUTHENIUM-CATALYZED CYCLOADDITION OF ALKYNES AND ORGANIC AZIDES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286405-A1 | Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides | CBR3, AOC3, CYB5R3 | HSD11B1 1498/4885SMN1; SMN2 4643/4885MAPK1 1106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.