Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 7/20 | 0.86 |
| ▸ | PGR | P06401 | 6/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.86 |
| ▸ | AR | P10275 | 4/20 | 0.86 |
| ▸ | USP2 | O75604 | 2/20 | 0.86 |
| ▸ | LMNA | P02545 | 6/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8904914 | 0.93 | NR3C1 (0.86) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL4335 | 0.92 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL13026159 | 0.92 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL10019829 | 0.92 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL8467031 | 0.92 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL24015431 | 0.92 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL5489567 | 0.92 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL5188866 | 0.92 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL4336 | 0.92 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL7861670 | 0.92 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011109711-A1 | GLUCOCORTICOID DRUGS AS SMOOTHENED AGONISTS | DUKE UNIVERSITY (US) | 2011-09-09 | — | — | WO | disclosed |