Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12104124 | 0.87 | NTSR1 (0.43) | ALDH1A1 | |
| SCHEMBL12323877 | 0.86 | PAX8 (0.39) | ACACBOPRM1HTR2AKCNA3OPRD1 | |
| SCHEMBL2738773 | 0.84 | KCNA3 (0.38) | ACACBOPRM1HTR2AKCNA3OPRD1 | |
| SCHEMBL684665 | 0.80 | OPRK1 (0.44) | OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL684411 | 0.80 | OPRK1 (0.44) | OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL12188328 | 0.73 | NTSR1 (0.45) | — | |
| SCHEMBL12188573 | 0.73 | NTSR1 (0.45) | — | |
| SCHEMBL12188576 | 0.73 | NTSR1 (0.45) | — | |
| SCHEMBL12188415 | 0.73 | SLC18A3 (0.44) | KCNA3ALDH1A1PAX8 | |
| SCHEMBL12219559 | 0.73 | NTSR1 (0.40) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049500-B1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-09-07 | — | — | EP | disclosed |