Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | TKT | P29401 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265097 | 0.87 | MAPT (0.50) | DAOTKTMAPTCYP3A4CYP3A5 | |
| SCHEMBL1120384 | 0.81 | GAA (0.49) | MAPTMEN1ALDH1A1KMT2AAURKA | |
| Hydrochloric Acid SCHEMBL119951 | 0.80 | GAA (0.48) | MAPTMEN1ALDH1A1KMT2AAURKA | |
| SCHEMBL934513 | 0.79 | GAA (0.46) | MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL20582056 | 0.76 | PLAAT3 (0.46) | DAOTKTCYP3A4CYP3A5KDM1A | |
| SCHEMBL265830 | 0.76 | HRH3 (0.48) | DAOTKTMAPTCYP3A4CYP3A5 | |
| SCHEMBL991931 | 0.73 | TAAR1 (0.52) | MAPTCYP3A4ALDH1A1KMT2ACYP2C19 | |
| SCHEMBL272264 | 0.73 | DAO (0.42) | DAOTKTMAPTMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL20582040 | 0.72 | DAO (0.46) | DAOTKTCYP3A4CYP3A5ALDH1A1 | |
| SCHEMBL263388 | 0.71 | MAPT (0.43) | DAOMAPTCYP3A4MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424364-A1 | PYRIDO [4,3-B] INDOLES AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010127177-A1 | PYRIDO [4,3-B] INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2010-11-04 | — | — | WO | disclosed |