Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19663000 | 0.80 | MAOA (0.40) | TOP2AMAOAGRM4WNT3ACYP19A1 | |
| SCHEMBL17691566 | 0.75 | MAPK10 (0.49) | AKT1CYP11B1TOP2AGRM4CYP19A1 | |
| SCHEMBL13177775 | 0.74 | CYP1A1 (0.45) | PRMT5WDR77CYP11B1CYP11B2GPR55 | |
| SCHEMBL12327333 | 0.73 | PRKCZ (0.43) | DYRK1A | |
| SCHEMBL3701838 | 0.72 | CYP1A2 (0.52) | CYP11B1CYP11B2TOP2AMAOAGRM4 | |
| SCHEMBL16118323 | 0.72 | CYP2A6 (0.56) | CYP11B1CYP11B2DYRK1ACYP19A1KDM4E | |
| SCHEMBL12326764 | 0.70 | TNF (0.43) | AKT1CYP11B1CYP11B2WNT3A | |
| SCHEMBL18848330 | 0.70 | MAOA (0.42) | TOP2AMAOAGRM4CYP19A1KDM4E | |
| SCHEMBL19663009 | 0.69 | MAOA (0.39) | TOP2AMAOAGRM4WNT3AKDM4E | |
| SCHEMBL23045962 | 0.68 | ABL1 (0.38) | AKT1CYP11B1CYP11B2GRM4WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366699-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2011-09-21 | — | — | EP | disclosed |