SCHEMBL19663000

SCHEMBL19663000

CCc1cc(C)c2cnccc2c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.40
KDM4E B2RXH2 3/20 0.39
HTT P42858 2/20 0.39
GRM4 Q14833 1/20 0.39
POLB P06746 1/20 0.39
RAD52 P43351 1/20 0.39
TOP2A P11388 1/20 0.38
HIPK2 Q9H2X6 2/20 0.36
BRD4 O60885 1/20 0.36
CREBBP Q92793 1/20 0.36
NCOA3 Q9Y6Q9 1/20 0.36
ALDH1A1 P00352 2/20 0.35
WNT3A P56704 1/20 0.35
APAF1 O14727 1/20 0.35
MAPT P10636 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ACHE P22303 1/20 0.34
NPSR1 Q6W5P4 1/20 0.33
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19663009 0.84 MAOA (0.39) MAOAKDM4EHTTGRM4POLB
SCHEMBL29923831 0.81 MAOA (0.39) MAOAKDM4EHTTPOLBRAD52
SCHEMBL12326845 0.80 AKT1 (0.43) MAOAKDM4EHTTGRM4POLB
SCHEMBL23717075 0.79 MAOA (0.57) MAOAKDM4ECREBBPALDH1A1MAPT
SCHEMBL21237375 0.78 HSPA5 (0.39) MAOAKDM4EHTTPOLBRAD52
SCHEMBL3701838 0.77 CYP1A2 (0.52) MAOAKDM4EHTTGRM4POLB
SCHEMBL31227991 0.76 MAOA (0.43) MAOAKDM4EHTTGRM4POLB
SCHEMBL24337886 0.75 PDE10A (0.46) KDM4EHTTALDH1A1APAF1MAPT
SCHEMBL2502937 0.74 MAOA (0.42) MAOAKDM4EHTTGRM4POLB
SCHEMBL31226961 0.74 MAOA (0.42) MAOAKDM4EHTTGRM4POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3464286-B1 PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER GENENTECH INC (US) 2021-08-18 EP disclosed
WO-2017205538-A1 PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER GENENTECH, INC. (US) 2017-11-30 WO disclosed