Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COASY | Q13057 | 1/20 | 0.47 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28277765 | 0.83 | COASY (0.46) | COASYACP3ADRB2ADRB1ADRB3 | |
| SCHEMBL15247597 | 0.83 | COASY (0.46) | COASYACP3ADRB2ADRB1ADRB3 | |
| SCHEMBL178548 | 0.82 | COASY (0.44) | COASYACP3ADRB2ADRB1ADRB3 | |
| SCHEMBL8246636 | 0.82 | COASY (0.44) | COASYACP3ADRB2ADRB1ADRB3 | |
| SCHEMBL11455315 | 0.80 | PNMT (0.44) | COASYACP3ADRB2ADRB1ADRB3 | |
| SCHEMBL25627915 | 0.80 | CASR (0.48) | COASYACP3ADRB2ADRB1ADRB3 | |
| SCHEMBL24176088 | 0.77 | ADRB1 (0.44) | COASYACP3ADRB2ADRB1ADRB3 | |
| SCHEMBL10087248 | 0.77 | ADRB2 (0.44) | COASYADRB2ADRB1ADRB3SLC2A1 | |
| SCHEMBL10087187 | 0.77 | SLC6A2 (0.51) | COASYACP3ADRB2ADRB1ADRB3 | |
| SCHEMBL14044305 | 0.77 | CASR (0.46) | COASYACP3ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364984-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-14 | — | — | EP | disclosed |