Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.48 |
| ▸ | PGK1 | P00558 | 2/20 | 0.42 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12330973 | 0.84 | TLR7 (0.56) | TLR7TLR8PGK1KMT5A | |
| SCHEMBL12330935 | 0.77 | TLR9 (0.52) | TLR7TLR8 | |
| SCHEMBL12330665 | 0.77 | TLR8 (0.47) | TLR7TLR8PGK1KMT5A | |
| SCHEMBL12330972 | 0.75 | TLR8 (0.45) | TLR7TLR8PGK1KMT5A | |
| SCHEMBL12330647 | 0.75 | PIK3CG (0.32) | — | |
| SCHEMBL12330986 | 0.69 | ACHE (0.47) | TLR7TLR8KMT5A | |
| SCHEMBL12655047 | 0.68 | HRH3 (0.48) | TLR7TLR8PGK1 | |
| SCHEMBL12654844 | 0.66 | PGK1 (0.40) | TLR7TLR8PGK1KMT5A | |
| SCHEMBL12330931 | 0.66 | PGK1 (0.47) | TLR7TLR8PGK1KMT5A | |
| SCHEMBL34462304 | 0.66 | ATM (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115183-A1 | NOVEL MONOCYCLIC PYRIMIDINE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2011-09-22 | — | — | WO | disclosed |