Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.47 |
| ▸ | PGK1 | P00558 | 4/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | KMT5A | Q9NQR1 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12330986 | 0.91 | ACHE (0.47) | TLR8TLR7KMT5AACHE | |
| SCHEMBL12330972 | 0.86 | TLR8 (0.45) | TLR8TLR7PGK1ACP1KMT5A | |
| SCHEMBL12330863 | 0.85 | TLR8 (0.36) | TLR8TLR7PGK1 | |
| SCHEMBL12331709 | 0.85 | TLR8 (0.36) | TLR8TLR7PGK1ACP1KMT5A | |
| SCHEMBL12330973 | 0.85 | TLR7 (0.56) | TLR8TLR7PGK1ACP1KMT5A | |
| SCHEMBL12175504 | 0.79 | ALDH1A1 (0.52) | PGK1 | |
| SCHEMBL12330670 | 0.79 | TLR9 (0.57) | ACHE | |
| SCHEMBL12330658 | 0.77 | TLR7 (0.48) | TLR8TLR7PGK1KMT5A | |
| SCHEMBL6415271 | 0.75 | TLR8 (0.58) | TLR8TLR7 | |
| SCHEMBL12330861 | 0.75 | TLR8 (0.46) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115183-A1 | NOVEL MONOCYCLIC PYRIMIDINE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2011-09-22 | — | — | WO | disclosed |