Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.36 |
| ▸ | PGK1 | P00558 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | KMT5A | Q9NQR1 | 2/20 | 0.31 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12330665 | 0.85 | TLR8 (0.47) | TLR8TLR7PGK1HRH3KMT5A | |
| SCHEMBL12330986 | 0.77 | ACHE (0.47) | TLR8TLR7CYP3A4TSHRKMT5A | |
| SCHEMBL12330863 | 0.75 | TLR8 (0.36) | TLR8TLR7PGK1KDM4EALDH1A1 | |
| SCHEMBL12330972 | 0.73 | TLR8 (0.45) | TLR8TLR7PGK1HRH3KMT5A | |
| SCHEMBL12330973 | 0.72 | TLR7 (0.56) | TLR8TLR7PGK1KMT5AACP1 | |
| SCHEMBL12175504 | 0.71 | ALDH1A1 (0.52) | PGK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12330944 | 0.71 | TLR9 (0.63) | TSHRTLR9 | |
| SCHEMBL12330670 | 0.69 | TLR9 (0.57) | ALDH1A1CYP3A4TSHRHSD17B10ACHE | |
| SCHEMBL12330861 | 0.68 | TLR8 (0.46) | TLR8TLR7KDM4EALDH1A1 | |
| SCHEMBL6415271 | 0.68 | TLR8 (0.58) | TLR8TLR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115183-A1 | NOVEL MONOCYCLIC PYRIMIDINE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2011-09-22 | — | — | WO | disclosed |