Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ATF1 | P18846 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31144917 | 0.84 | PLA2G2A (0.47) | RHOCRHOAGAAALDH1A1MAOB | |
| SCHEMBL31144862 | 0.81 | GPBAR1 (0.46) | RHOCRHOASCN9AGAAALDH1A1 | |
| SCHEMBL12130271 | 0.79 | AURKA (0.47) | ALDH1A1KDM4EMAOBAURKARPS6KB1 | |
| SCHEMBL6309831 | 0.75 | PARP10 (0.62) | ALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL31144953 | 0.74 | PARP1 (0.50) | GAAKDM4ENOTUMMAOBRXRA | |
| SCHEMBL628410 | 0.74 | PARP1 (0.50) | GAAKDM4ENOTUMMAOBRXRA | |
| SCHEMBL26146858 | 0.74 | MAOB (0.40) | SCN9AGAAKDM4ENOTUMMAOB | |
| SCHEMBL12130332 | 0.73 | LTA4H (0.52) | GAAALDH1A1KDM4EAURKARPS6KB1 | |
| SCHEMBL31144913 | 0.72 | NOTUM (0.58) | RHOCRHOAALDH1A1NOTUMMAPT | |
| SCHEMBL17056237 | 0.71 | PLA2G2A (0.63) | FAAHTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011109799-A1 | NUCLEAR TRANSPORT MODULATIORS AND USES THEREOF | KARYOPHARM THERAPEUTICS, INC. (US) | 2011-09-09 | — | — | WO | disclosed |