Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | C1S | P09871 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587300 | 0.84 | MAPT (0.46) | CTSLCTSBHTTSMN1; SMN2GAA | |
| SCHEMBL3371815 | 0.84 | PRSS1 (0.56) | PRSS1PRSS2C1SPRSS3HTT | |
| SCHEMBL22383502 | 0.78 | PARP1 (0.50) | PRSS1PRSS2C1SPRSS3HTT | |
| SCHEMBL11526256 | 0.78 | PARP1 (0.50) | PRSS1PRSS2C1SPRSS3HTT | |
| SCHEMBL12876024 | 0.74 | SMN1; SMN2 (0.42) | CTSLCTSBPRSS1PRSS2C1S | |
| SCHEMBL18004027 | 0.74 | TAS1R3 (0.36) | CTSLCTSBHTTSMN1; SMN2GAA | |
| SCHEMBL26326385 | 0.74 | PRSS1 (0.41) | PRSS1PRSS2C1SPRSS3HTT | |
| SCHEMBL12127523 | 0.74 | ALDH1A1 (0.44) | CTSLCTSBHTTSMN1; SMN2GAA | |
| SCHEMBL23965606 | 0.71 | PRSS1 (0.43) | CTSLCTSBPRSS1PRSS2C1S | |
| SCHEMBL2172133 | 0.71 | TPMT (0.70) | SMN1; SMN2ALDH1A1TPMTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011109799-A1 | NUCLEAR TRANSPORT MODULATIORS AND USES THEREOF | KARYOPHARM THERAPEUTICS, INC. (US) | 2011-09-09 | — | — | WO | disclosed |