Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 5/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078069 | 0.93 | CTSS (0.42) | KLK5APPPSEN1PSEN2APH1B | |
| SCHEMBL12291410 | 0.91 | KLK5 (0.45) | KLK5APPPSEN1PSEN2APH1B | |
| SCHEMBL10075284 | 0.87 | CTSS (0.40) | KLK5SCN9ACTSSCTSKDPP4 | |
| SCHEMBL6873681 | 0.86 | LAP3 (0.44) | DPP4DPP7 | |
| SCHEMBL13195308 | 0.85 | ENPP2 (0.43) | DPP4DPP7PTPN1 | |
| SCHEMBL13195340 | 0.85 | KLK5 (0.42) | KLK5APPPSEN1PSEN2APH1B | |
| SCHEMBL6872873 | 0.85 | ATM (0.48) | KLK5APPPSEN1PSEN2APH1B | |
| SCHEMBL10074460 | 0.84 | CTSS (0.42) | KLK5SCN9ACTSSCTSKPTPN1 | |
| SCHEMBL10074141 | 0.84 | CTSS (0.42) | KLK5SCN9ACTSSCTSKPTPN1 | |
| SCHEMBL12849466 | 0.83 | KLK5 (0.42) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113895-A2 | CHARACTERIZATION AND VALIDATION OF INHIBITORS AND LIGANDS OF DIPEPTIDYL AMINOPEPTIDASE IV (DP IV) | IMTM GMBH (DE) | 2011-09-22 | — | — | WO | disclosed |