Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rathyronine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 14/20 | 1.00 |
| ▸ | THRA known ✓ | P10827 | 10/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | PCNA | P12004 | 4/20 | 1.00 |
| ▸ | PPARG | P37231 | 4/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 2/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 2/20 | 1.00 |
| ▸ | GABRB2 | P47870 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | GABRP | O00591 | 1/20 | 1.00 |
| ▸ | GABRD | O14764 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | GABRB1 | P18505 | 1/20 | 1.00 |
| ▸ | GABRG2 | P18507 | 1/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Detrothyronine SCHEMBL29651848 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL29383803 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL3287278 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL29390909 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL8300 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL8301 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL4608153 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL2679283 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL21749451 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL438744 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2517 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025085899-A1 | PRODUCTION OF SALIVARY GLAND EPITHELIAL PROGENITORS AND SALIVARY GLAND CELL ORGANOIDS FOR REGENERATIVE MEDICINE AND DRUG TESTING PURPOSES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2025-04-24 | — | — | WO | claimed |
| EP-3522825-B1 | IMPLANTABLE DEVICES FOR DRUG DELIVERY WITH REDUCED BURST RELEASE | TITAN PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | claimed |
| EP-3908272-B1 | L-TRIIODOTHYRONINE (T3) FOR USE IN LIMITING MICROVASCULAR OBSTRUCTION | UNI PHARMA KLEON TSETIS PHARMACEUTICAL LABORATORIES S A (GR) | 2023-03-22 | — | — | EP | claimed |
| EP-4138810-A1 | PHARMACEUTICAL COMPOSITION COMPRISING L-TRIIODOTHYRONINE (T3) FOR USE IN THE TREATMENT OF TISSUE HYPOXEMIA AND SEPSIS | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. (GR) | 2023-03-01 | — | — | EP | claimed |
| US-20220265775-A1 | COMPOSITIONS AND METHODS FOR TREATING PULMONARY EDEMA OR LUNG INFLAMMATION | UNIV MINNESOTA (US) | 2022-08-25 | — | — | US | claimed |
| EP-3955954-A1 | COMBINATION THERAPY FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES | NGM Biopharmaceuticals, Inc. (US) | 2022-02-23 | — | — | EP | claimed |
| US-20200390858-A1 | Combination Therapy for Modulating Bile Acid Homeostasis and Treatment of Bile Acid Disorders and Diseases | NGM BIOPHARMACEUTICALS, INC. | 2020-12-17 | — | — | US | claimed |
| WO-2020214753-A1 | COMBINATION THERAPY FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES | NGM BIOPHARMACEUTICALS, INC. (US) | 2020-10-22 | — | — | WO | claimed |
| US-20200222348-A1 | BIMODAL MODIFIED RELEASE COMPOSITIONS FOR CANCER TREATMENT | MUSLI THYROPEUTICS LTD. (IL) | 2020-07-16 | — | — | US | claimed |
| US-10053445-B2 | Photocleavable chemical inducers of dimerization (CID) and methods of use | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2018-08-21 | — | — | US | claimed |
| US-4711855-A | Derivatives of 3,5,3-triiodothyronine | CIBA CORNING DIAGNOSTICS CORP. (US) | 1987-12-08 | — | — | US | claimed |
| US-4673691-A | CONCURRENT ADMINISTRATION OF 2,4-DINITROPHENOL AND 3,5,3*-TRI IODOTHYRONINE | Bachynsky, Nicholas (US) | 1987-06-16 | — | — | US | claimed |
| EP-0165669-A1 | Improved method of measuring free ligand | Corning Glass Works (US) | 1985-12-27 | — | — | EP | claimed |
| EP-0093653-B1 | PROCESS FOR THE PREPARATION OF IODO-THYRONINES AND IODO-THYROACETIC ACIDS BY ELECTROCHEMICAL REDUCTION AT A CONTROLLED POTENTIAL | SPIRAL Société à responsabilité limitée dite : (FR) | 1985-07-10 | — | — | EP | claimed |
| US-4490221-A | Process for preparing iodothyronines and iodothyroacetic acids by electrochemical reduction at controlled potential | SPIRAL SOCIETE A RESPONSABILITE LIMITEE DITE (FR) | 1984-12-25 | — | — | US | claimed |
| EP-0049860-B1 | PROCESS FOR THE PREPARATION OF REACTIVE THYROID GLAND HORMONES T3 AND T4 DERIVATIVES THAT ARE CAPABLE OF COUPLING, AND THEIR USE | Roche Diagnostics GmbH (DE) | 1984-10-03 | — | — | EP | claimed |
| US-4423227-A | SILYLATION, ACYLATION | BOEHRINGER MANNHEIM GMBH (DE) | 1983-12-27 | — | — | US | claimed |
| US-4410633-A | IMMUNOASSAY | CORNING GLASS WORKS (US) | 1983-10-18 | — | — | US | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |
| US-4299812-A | Immunoassay of thyroxine in neonates using dried blood samples | DIAGNOSTIC PRODUCTS CORP. (US) | 1981-11-10 | — | — | US | claimed |