Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Detrothyronine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 14/20 | 1.00 |
| ▸ | THRA known ✓ | P10827 | 10/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | PCNA | P12004 | 4/20 | 1.00 |
| ▸ | PPARG | P37231 | 4/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 2/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 2/20 | 1.00 |
| ▸ | GABRB2 | P47870 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | GABRP | O00591 | 1/20 | 1.00 |
| ▸ | GABRD | O14764 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | GABRB1 | P18505 | 1/20 | 1.00 |
| ▸ | GABRG2 | P18507 | 1/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Detrothyronine SCHEMBL29651848 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL29383803 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL3287278 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL29390909 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Rathyronine SCHEMBL123365 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL8300 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL4608153 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL2679283 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL21749451 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL438744 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1677 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4733383-A1 | CULTURE MEDIUM AND BLOOD CELL CLONE, AND METHOD FOR PRODUCING SAME | Japan Institute for Health Security (JP) | 2026-04-29 | — | — | EP | claimed |
| US-12516295-B2 | Generation of pancreatic progenitor cells and beta cells from human pluripotent stem cells | THE PENN STATE RESEARCH FOUNDATION (US) | 2026-01-06 | — | — | US | claimed |
| US-20250197803-A1 | A METHOD OF DIFFERENTIATING AN INDUCED PLURIPOTENT STEM CELL INTO A RETINAL PIGMENT EPITHELIAL CELL, A RETINAL PIGMENT EPITHELIAL CELL AND METHODS OF USING THE RETINAL PIGMENT EPITHELIAL CELL | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2025-06-19 | — | — | US | claimed |
| US-12312599-B2 | Methods, compositions, and kits for producing beige adipocytes and treating metabolic disorders | MaineHealth (US) | 2025-05-27 | — | — | US | claimed |
| EP-4556556-A1 | METHOD FOR PURIFICATION AND PRODUCTION OF VENTRICULAR CARDIOMYOCYTES | T&R Biofab Co., Ltd. (KR) | 2025-05-21 | — | — | EP | claimed |
| US-20250111893-A1 | SYSTEMS AND METHODS FOR CUSTOMIZING CELL CULTURE MEDIA FOR OPTIMIZED CELL PROLIFERATION BASED ON GENETIC TRAITS OF CELLS | WONDERLAB HOLDINGS, INC. | 2025-04-03 | — | — | US | claimed |
| WO-2024262610-A1 | CULTURE MEDIUM AND BLOOD CELL CLONE, AND METHOD FOR PRODUCING SAME | 国立研究開発法人国立国際医療研究センター | 2024-12-26 | — | — | WO | claimed |
| CN-119101652-A | Method for separating and culturing rat oligodendrocyte precursor cells | 西安交通大学医学院第二附属医院 | 2024-12-10 | — | — | CN | claimed |
| EP-4469561-A2 | A METHOD OF DIFFERENTIATING AN INDUCED PLURIPOTENT STEM CELL INTO A RETINAL PIGMENT EPITHELIAL CELL, A RETINAL PIGMENT EPITHELIAL CELL AND METHODS OF USING THE RETINAL PIGMENT EPITHELIAL CELL | Agency for Science, Technology and Research (SG) | 2024-12-04 | — | — | EP | claimed |
| EP-3523421-B1 | A METHOD OF ISOLATING MESENCHYMAL STEM CELLS FROM UMBILICAL CORD AMNIOTIC MEMBRANE USING A CELL CULTURE MEDIUM | CELLRESEARCH CORP PTE LTD (SG) | 2024-12-04 | — | — | EP | claimed |
| WO-1995020954-A1 | TABLETS CONTAINING THYROID HORMONES | KNOLL AG (DE) | 1995-08-10 | — | — | WO | claimed |
| US-5169984-A | One step bromoacetylation of 3,3',5-triodo-l-thyronine with bromoacetyl bromide | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1992-12-08 | — | — | US | claimed |
| US-5168102-A | Administering thyroid hormone to decrease fat deposits | UNIVERSITY OF DELAWARE (US) | 1992-12-01 | — | — | US | claimed |
| US-5162302-A | Thyroid Hormone, Growth Hormone Releasing Factor or Thyrotropin Releasing Hormone | UNIVERSITY OF DELAWARE (US) | 1992-11-10 | — | — | US | claimed |
| EP-0358754-A4 | ENDOCRINE MANIPULATION TO IMPROVE BODY COMPOSITION OF POULTRY | — | 1991-06-26 | — | — | EP | claimed |
| US-4929600-A | THYROID HORMONES, ANTIFAT AGENTS | UNIVERSITY OF DELEWARE (US) | 1990-05-29 | — | — | US | claimed |
| EP-0358754-A1 | ENDOCRINE MANIPULATION TO IMPROVE BODY COMPOSITION OF POULTRY | UNIVERSITY OF DELAWARE (US) | 1990-03-21 | — | — | EP | claimed |
| US-4870106-A | THYROXINE AND 3,5,3'-TRIIODOTHYRONINE | THE HOSPITAL ATTACHED TO TIANJIN ACADEMY OF MEDICAL SCIENCES (CN) | 1989-09-26 | — | — | US | claimed |
| WO-1989008458-A1 | ENDOCRINE MANIPULATION TO IMPROVE BODY COMPOSITION OF POULTRY | UNIVERSITY OF DELAWARE (US) | 1989-09-21 | — | — | WO | claimed |
| EP-0103784-B1 | CATALYZED COLORIMETRIC AND FLUOROMETRIC SUBSTRATES FOR PEROXIDASE ENZYME DETERMINATIONS | ENZYME TECHNOLOGY COMPANY (US) | 1988-01-07 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12312599-B2 | Methods, compositions, and kits for producing beige adipocytes and treating metabolic disorders | FABP4, LIPC, PNLIP | THRB 2052/4885THRA 1435/4885LMNA 511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.