Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Liothyronine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 14/20 | 1.00 |
| ▸ | THRA known ✓ | P10827 | 10/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | PCNA | P12004 | 4/20 | 1.00 |
| ▸ | PPARG | P37231 | 4/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 2/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 2/20 | 1.00 |
| ▸ | GABRB2 | P47870 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | GABRP | O00591 | 1/20 | 1.00 |
| ▸ | GABRD | O14764 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | GABRB1 | P18505 | 1/20 | 1.00 |
| ▸ | GABRG2 | P18507 | 1/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Detrothyronine SCHEMBL29651848 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL29383803 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL3287278 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL29390909 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Rathyronine SCHEMBL123365 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL8301 | 1.00 | THRB (1.00) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL4608153 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL2679283 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Detrothyronine SCHEMBL21749451 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A | |
| Liothyronine SCHEMBL438744 | 0.99 | THRB (0.97) | THRBTHRALMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 26298 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746923-A2 | DELIVERY SYSTEM COMPRISING LIPID OR POLYMERIC NANOPARTICLES COMPRISING THYROID HORMONES | FONDAZIONE RICCARDO TERZI E SILVIO ALBINI (IT) | 2026-05-27 | — | — | EP | claimed |
| EP-4747627-A1 | METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS | Matterworks Inc (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4747643-A1 | DEVICES AND METHODS FOR IMMUNOASSAY ANALYSIS OF BIOLOGICAL SAMPLES | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| US-12636270-B2 | Levothyroxine liquid formulations | FRESENIUS KABI USA, LLC (US) | 2026-05-26 | — | — | US | claimed |
| CN-122084582-A | Auxiliary kit for detecting content of calcium ions in cells | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075464-A | First-aid product and method for losing temperature protection in low-temperature environment | — | 2026-05-26 | — | — | CN | claimed |
| CN-122084916-A | Fluorescent sensor for detecting endocrine disrupting activity in sewage and application | — | 2026-05-26 | — | — | CN | claimed |
| US-20260140444-A1 | PHOTORESIST COMPOSITION AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE | TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) | 2026-05-21 | — | — | US | claimed |
| EP-4745225-A1 | SERUM-FREE NUTRIENT COMPOSITION FOR THE CULTIVATION OF VERTEBRATE CELLS | The Cultivated B. GmbH (DE) | 2026-05-20 | — | — | EP | claimed |
| CN-122057050-A | Application of urine-derived stem cells in ED treatment | 潍坊吉涛医学科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-4155711-A | Method and apparatus for determining thyroid function of multiple samples | SMUTKO RAYMOND A | 1979-05-22 | — | — | US | claimed |
| US-4119709-A | COMPETITIVE BINDING, RADIOACTIVE ISOTOPES | HOLUB WILLIAM R | 1978-10-10 | — | — | US | claimed |
| US-4113433-A | RADIOIMMUNOASSAY OF HORMONES AND METABOLITES IN BLOOD SERUM AND PLASMA | KHARE GYANESHWAR PRASAD | 1978-09-12 | — | — | US | claimed |
| US-4108974-A | ANTIBODIES BOUND TO POLYACRYLAMIDE | BIO-RAD LABORATORIES, INC. (US) | 1978-08-22 | — | — | US | claimed |
| US-4107284-A | Radioimmunoassay procedure using a stabilized complex | SULTANIAN ISHKHAN V | 1978-08-15 | — | — | US | claimed |
| US-4066410-A | RADIOACTIVE HORMONE BINDS TO ANTIBODIES | NUCLEAR-MEDICAL LABORATORIES, INC. (US) | 1978-01-03 | — | — | US | claimed |
| US-4034073-A | Composite for biased solid phase radioimmunoassay of triiodothyronine and thyroxine | CORNING GLASS WORKS (US) | 1977-07-05 | — | — | US | claimed |
| US-3995019-A | FOR RADIOIMMUNOASSAY CONSISTING OF A SPECIFIC ANTIBODY RADIOLABELED, ANTIGEN, POLYETHYLENE GLYCOL, AND GAMMA GLOBULIN | BAXTER TRAVENOL LABORATORIES, INC. (US) | 1976-11-30 | — | — | US | claimed |
| US-3961894-A | RADIOACTIVELY LABELED | YISSUM RESEARCH DEVELOPMENT COMPANY (IL) | 1976-06-08 | — | — | US | claimed |
| US-3962039-A | PEPSIN | CENTER FOR LABORATORY MEDICINE (US) | 1976-06-08 | — | — | US | claimed |