Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12342106 | 0.90 | CSF1R (0.51) | CSF1RLTA4HCYP2C19KITRPS6KB1 | |
| SCHEMBL12338612 | 0.90 | CSF1R (0.41) | CSF1RLTA4HCYP2C19KITCCNA2 | |
| SCHEMBL14147163 | 0.85 | KDR (0.44) | CSF1RCYP2C19RPS6KB1CYP1A2 | |
| SCHEMBL12338615 | 0.84 | CSF1R (0.57) | CSF1RLTA4HCYP2C19KITCYP1A2 | |
| SCHEMBL12341431 | 0.83 | CSF1R (0.49) | CSF1RKITRPS6KB1BRD4 | |
| SCHEMBL12342108 | 0.81 | CSF1R (0.54) | CSF1RLTA4HCYP2C19KITRPS6KB1 | |
| SCHEMBL14147160 | 0.77 | CSF1R (0.42) | CSF1RCYP2C19KITBRD4CYP1A2 | |
| SCHEMBL12341853 | 0.75 | CSF1R (0.54) | CSF1RCYP2C19KITRPS6KB1BRD4 | |
| SCHEMBL12342164 | 0.75 | CSF1R (0.52) | CSF1RCYP2C19KITRPS6KB1 | |
| SCHEMBL12341433 | 0.74 | CSF1R (0.53) | CSF1RCYP2C19KITRPS6KB1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268858-B2 | e.g. 5-(3-methoxybenzyloxy)-1H-pyrrolo[2,3-b]pyridine; protein kinases inhibitor; central nervous system disorders; Alzheimer's disease; Parkinson's disease; anticancer, antitumor agents; analgesics; cogestive heart failure; skin disorders; inflammatory bowel disorders; transplant rejection | PLEXXIKON INC. (US) | 2012-09-18 | — | — | US | disclosed |