Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.81 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.81 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.66 |
| ▸ | HTR2C | P28335 | 1/20 | 0.66 |
| ▸ | HTR2B | P41595 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28742702 | 0.94 | HDAC1 (0.81) | HDAC1HDAC4KCNH2HDAC6HDAC8 | |
| SCHEMBL9407904 | 0.89 | HDAC4 (0.72) | HDAC1HDAC4KCNH2HDAC6HDAC8 | |
| SCHEMBL28742676 | 0.86 | HDAC1 (0.64) | HDAC1HDAC4KCNH2HDAC6HDAC8 | |
| SCHEMBL1066467 | 0.85 | HTR2A (0.72) | HDAC1HDAC4KCNH2HDAC6HDAC8 | |
| Hydrochloric Acid SCHEMBL4653252 | 0.84 | HTR2A (0.71) | HDAC1HDAC4KCNH2HDAC6HDAC8 | |
| SCHEMBL7459360 | 0.84 | HTR2A (0.71) | HDAC1HDAC4KCNH2HDAC6HDAC8 | |
| SCHEMBL1482123 | 0.83 | HTR2A (0.69) | HDAC1HDAC4HDAC6HDAC8HDAC3 | |
| SCHEMBL2744427 | 0.83 | HTR2A (0.69) | HDAC1HDAC4HDAC6HDAC8HDAC3 | |
| SCHEMBL20394950 | 0.83 | ALDH1A1 (0.75) | HDAC1HDAC4KCNH2HDAC6HDAC8 | |
| SCHEMBL4653292 | 0.82 | MAPT (0.66) | HDAC1HDAC4HDAC6HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343988-B2 | Inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V (BE) | 2013-01-01 | — | — | US | disclosed |
| US-8343988-B2 | Inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V (BE) | 2013-01-01 | — | — | US | disclosed |
| US-8268833-B2 | Inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2012-09-18 | — | — | US | disclosed |
| US-8268833-B2 | Inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2012-09-18 | — | — | US | disclosed |
| US-7868205-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868205-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7816363-B2 | to inhibit proliferative conditions, such as cancer and psoriasis; detecting or identifying a HDAC in a biological sample comprising detecting or measuring the formation of a complex between a labelled compound as defined in claim (I) and a HDAC | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-10-19 | — | — | US | disclosed |
| US-7816363-B2 | to inhibit proliferative conditions, such as cancer and psoriasis; detecting or identifying a HDAC in a biological sample comprising detecting or measuring the formation of a complex between a labelled compound as defined in claim (I) and a HDAC | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-10-19 | — | — | US | disclosed |
| US-20090170881-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | ANGIBAUD PATRICK RENE | 2009-07-02 | — | — | US | disclosed |
| US-20090170836-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | ANGIBAUD PATRICK RENE | 2009-07-02 | — | — | US | disclosed |
| US-20090170836-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | ANGIBAUD PATRICK RENE | 2009-07-02 | — | — | US | disclosed |
| US-20090170881-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | ANGIBAUD PATRICK RENE | 2009-07-02 | — | — | US | disclosed |
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | METHYLGENE, INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | METHYLGENE, INC. (CA) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885HDAC4 8/4885KCNH2 4025/4885 |
| US-20090170836-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC11 | HDAC1 1/4885HDAC4 6/4885KCNH2 2741/4885 |
| US-20090170881-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC11 | HDAC1 1/4885HDAC4 6/4885KCNH2 2741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.