Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | BAD | Q92934 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8485036 | 0.98 | BCL2L1 (0.47) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Terephthalic Acid SCHEMBL28622230 | 0.96 | TSHR (0.46) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Terephthalic Acid SCHEMBL10383269 | 0.95 | TSHR (0.41) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Terephthalic Acid SCHEMBL3979457 | 0.92 | TSHR (0.50) | TSHRTP53NPC1RAB9ABCL2L1 | |
| SCHEMBL5319785 | 0.90 | BCL2L1 (0.50) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Isophthalic Acid SCHEMBL472832 | 0.89 | KMO (0.47) | NPC1RAB9AALDH1A1RXRARXRB | |
| Terephthalic Acid SCHEMBL28482093 | 0.89 | SMN1; SMN2 (0.42) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Terephthalic Acid SCHEMBL28279901 | 0.89 | TSHR (0.46) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Terephthalic Acid SCHEMBL11133121 | 0.88 | RARB (0.48) | TP53NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL7058234 | 0.88 | RARB (0.48) | TP53NPC1RAB9AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459646-A2 | TOUGHENED POLYTRIMETHYLENE TEREPHTHALATE RESIN COMPOSITION | E. I. du Pont de Nemours and Company (US) | 2012-06-06 | — | — | EP | claimed |
| WO-2011014646-A2 | TOUGHENED POLYTRIMETHYLENE TEREPHTHALATE RESIN COMPOSITION | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-02-03 | — | — | WO | claimed |
| CN-111718569-B | Method for recovering polyglycolic acid and application thereof | 上海浦景化工技术股份有限公司 | 2022-07-19 | — | — | CN | disclosed |
| CN-110859099-B | Degradable seedling raising tray and preparation method thereof | 河南青源天仁生物技术有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-111718569-A | Method for recovering polyglycolic acid and application thereof | 上海浦景化工技术股份有限公司 | 2020-09-29 | — | — | CN | disclosed |
| CN-110859099-A | Degradable seedling raising tray and preparation method thereof | 河南青源天仁生物技术有限公司 | 2020-03-06 | — | — | CN | disclosed |
| CN-106350887-A | Porous PBT fiber POY yarn and preparation method thereof | 江苏恒力化纤股份有限公司 | 2017-01-25 | — | — | CN | disclosed |
| CN-105860043-A | Thermoplastic polyester for antibacterial film and preparation method of thermoplastic polyester | 苍南县宝丰印业有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105860044-A | Thermoplastic polyester for films and preparation method thereof | 苍南县宝丰印业有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105837810-A | Thermoplastic polyester for antibacterial film and preparation method for thermoplastic polyester | 苍南县宝丰印业有限公司 | 2016-08-10 | — | — | CN | disclosed |
| EP-0892721-A1 | MULTILAYER CARD | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997037849-A1 | MULTILAYER CARD | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1997-10-16 | — | — | WO | disclosed |