Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | BAD | Q92934 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL1234263 | 0.96 | TSHR (0.46) | TSHRTP53NPC1RAB9ABCL2L1 | |
| SCHEMBL8485036 | 0.94 | BCL2L1 (0.47) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Terephthalic Acid SCHEMBL3979457 | 0.92 | TSHR (0.50) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Terephthalic Acid SCHEMBL10383269 | 0.91 | TSHR (0.41) | TSHRTP53NPC1RAB9ABCL2L1 | |
| SCHEMBL5319785 | 0.90 | BCL2L1 (0.50) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Terephthalic Acid SCHEMBL28279901 | 0.89 | TSHR (0.46) | TSHRTP53NPC1RAB9ABCL2L1 | |
| SCHEMBL7058234 | 0.88 | RARB (0.48) | TP53NPC1RAB9A | |
| Terephthalic Acid SCHEMBL28482093 | 0.85 | SMN1; SMN2 (0.42) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Terephthalic Acid SCHEMBL2463379 | 0.85 | NPC1 (0.46) | TSHRTP53NPC1RAB9ABCL2L1 | |
| Isophthalic Acid SCHEMBL472832 | 0.85 | KMO (0.47) | NPC1RAB9ARXRARXRBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113430159-A | Bionic extracellular matrix bioactive substance coating polyester reticular lamellar scaffold | 广东乾晖生物科技有限公司 | 2021-09-24 | — | — | CN | claimed |
| CN-113430159-B | Bionic extracellular matrix bioactive substance coating polyester reticular lamellar scaffold | 广东乾晖生物科技有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-113430159-A | Bionic extracellular matrix bioactive substance coating polyester reticular lamellar scaffold | 广东乾晖生物科技有限公司 | 2021-09-24 | — | — | CN | disclosed |