SCHEMBL12349305

SCHEMBL12349305

O=S1(=O)c2ccccc2N(c2ccc([Si](c3ccccc3)(c3ccccc3)c3ccccc3)cc2)c2ccccc21

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 2/20 0.44
TP53 P04637 2/20 0.37
LMNA P02545 5/20 0.36
MAPT P10636 2/20 0.36
THRB P10828 1/20 0.36
POLB P06746 1/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
GPR3 P46089 1/20 0.35
NOX1 Q9Y5S8 1/20 0.32
GAA P10253 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
MAOA P21397 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12349312 1.00 RXFP1 (0.44) RXFP1TP53LMNAMAPTTHRB
SCHEMBL12349299 0.97 RXFP1 (0.42) RXFP1TP53LMNAMAPTTHRB
SCHEMBL12349324 0.90 RXFP1 (0.37) RXFP1TP53LMNAMAPTTHRB
SCHEMBL12349317 0.88 KDM4E (0.42) RXFP1TP53LMNAMAPTTHRB
SCHEMBL12349314 0.87 RXFP1 (0.41) RXFP1TP53LMNAMAPTTHRB
SCHEMBL12190900 0.86 RXFP1 (0.50) RXFP1TP53LMNAMAPTTHRB
SCHEMBL12349296 0.85 RXFP1 (0.41) RXFP1TP53LMNAMAPTTHRB
SCHEMBL2498455 0.84 RXFP1 (0.53) RXFP1TP53LMNAMAPTTHRB
SCHEMBL12349325 0.83 KDM4E (0.36) RXFP1MEN1KMT2A
SCHEMBL12349307 0.83 MAPT (0.40) RXFP1TP53LMNAMAPTTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7989091-B2 Silanes containing phenothiazine-S-oxide or phenothiazine-S,S-dioxide groups and the use thereof in OLEDs BASF SE (DE) 2011-08-02 US disclosed
US-20100187980-A1 SILANES CONTAINING PHENOTHIAZINE-S-OXIDE OR PHENOTHIAZINE-S,S-DIOXIDE GROUPS AND THE USE THEREOF IN OLEDS BASF SE (DE) 2010-07-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100187980-A1 SILANES CONTAINING PHENOTHIAZINE-S-OXIDE OR PHENOTHIAZINE-S,S-DIOXIDE GROUPS AND THE USE THEREOF IN OLEDS OPRD1, PPID, PLOD2 RXFP1 4373/4885TP53 3059/4885LMNA 2054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.