Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 6/20 | 0.60 |
| ▸ | KCNQ2 | O43526 | 6/20 | 0.60 |
| ▸ | KCNE1 | P15382 | 6/20 | 0.60 |
| ▸ | KCNQ1 | P51787 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.53 |
| ▸ | MDM4 | O15151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | LIPE | Q05469 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302927 | 0.89 | ALDH1A1 (0.64) | KCNQ3KCNQ2KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL1233691 | 0.84 | HDAC1 (0.68) | KCNQ3KCNQ2KCNE1KCNQ1MDM4 | |
| SCHEMBL1235368 | 0.83 | HDAC1 (0.60) | KCNQ3KCNQ2KCNE1KCNQ1MDM4 | |
| SCHEMBL14967989 | 0.81 | PTGS1 (0.51) | PTGS1HDAC1LIPEKMT2A | |
| SCHEMBL24178169 | 0.81 | ALDH1A1 (0.58) | KCNQ3KCNQ2KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL6705957 | 0.81 | KCNMA1 (0.56) | KCNQ3KCNQ2KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL1235341 | 0.81 | RAB9A (0.63) | KCNQ3KCNQ2KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL1236023 | 0.81 | PTGS1 (0.51) | PTGS1HDAC1KMT2A | |
| SCHEMBL360849 | 0.80 | PTGS1 (0.49) | PTGS1HDAC1LIPECYP1A2CYP2C19 | |
| SCHEMBL14453684 | 0.79 | PTGS1 (0.61) | PTGS1HDAC1KDRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| EP-2285376-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | Chipscreen Biosciences Ltd. (CN) | 2011-02-23 | — | — | EP | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
| WO-2009140164-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES LTD. (CN) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009140164-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES LTD. (CN) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC2, HDAC3 | KCNQ3 3519/4885KCNQ2 2939/4885KCNE1 3090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.