Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6770901 | 0.82 | HTR2C (0.56) | HTR3AHTR2CHTR3EHTR3BHTR1A | |
| SCHEMBL6771824 | 0.79 | CYP1A2 (0.56) | HTR3AALDH1A1 | |
| SCHEMBL12354287 | 0.78 | HTR3A (0.50) | HTR3AHTR2CHTR3EHTR3BHTR1A | |
| SCHEMBL12354269 | 0.78 | HTR3E (0.55) | HTR3AHTR2CHTR3EHTR3BHTR1A | |
| SCHEMBL1106498 | 0.71 | CSNK1E (0.47) | TP53TSHRKDM4EALDH1A1 | |
| SCHEMBL21363710 | 0.70 | CYP1A2 (0.41) | TP53TSHRKDM4E | |
| SCHEMBL12354239 | 0.70 | PDE2A (0.43) | TP53TSHR | |
| SCHEMBL21924776 | 0.70 | PDE10A (0.39) | TP53TSHRALDH1A1 | |
| SCHEMBL16939382 | 0.70 | PDE10A (0.43) | TP53TSHRALDH1A1 | |
| SCHEMBL12464592 | 0.70 | KDM4E (0.42) | TP53TSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994173-B2 | 2-piperazin-1-yl-3H-imidazo[4,5-b]pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-09 | — | — | US | disclosed |
| US-7994173-B2 | 2-piperazin-1-yl-3H-imidazo[4,5-b]pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-09 | — | — | US | disclosed |
| US-20100004260-A1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-07 | — | — | US | disclosed |
| US-20100004260-A1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004260-A1 | 2-PIPERAZIN-1-YL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES | PDE3A, PDE3B, PTGIS | HTR3A 326/4885HTR2C 252/4885HTR3E 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.