Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1080847 | 0.78 | GPR35 (0.39) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL1573308 | 0.77 | TDP1 (0.38) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL11444096 | 0.73 | TDP1 (0.42) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL5916971 | 0.73 | GPR35 (0.46) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL3256630 | 0.73 | IDO1 (0.52) | PNMT | |
| SCHEMBL12355681 | 0.73 | PNMT (0.49) | PNMT | |
| SCHEMBL14017372 | 0.70 | TDP1 (0.44) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL7909196 | 0.70 | ACHE (0.42) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL1080845 | 0.70 | TDP1 (0.44) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL2246781 | 0.70 | GPR35 (0.42) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989451-B2 | Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments | AUCKLAND UNISERVICES LIMITED (NZ) | 2011-08-02 | — | — | US | disclosed |