Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12359234 | 0.85 | RAB9A (0.53) | RAB9ASMN1; SMN2LMNANPC1PDE10A | |
| SCHEMBL12358874 | 0.81 | TRPV1 (0.45) | RAB9ASMN1; SMN2LMNANPC1PDE10A | |
| SCHEMBL2240813 | 0.81 | TRPV1 (0.56) | LMNAPDE10APRKAG1PRKAA2PRKAB1 | |
| Hydrochloric Acid SCHEMBL27138714 | 0.76 | MAOB (0.50) | RAB9ANPC1PDE10APRKAG1PRKAA2 | |
| Hydrochloric Acid SCHEMBL30033809 | 0.76 | MAOB (0.50) | RAB9ANPC1PDE10APRKAG1PRKAA2 | |
| SCHEMBL12359134 | 0.76 | TRPV1 (0.45) | RAB9ASMN1; SMN2LMNANPC1PDE10A | |
| SCHEMBL12359287 | 0.75 | NPC1 (0.48) | RAB9ASMN1; SMN2LMNANPC1MAPT | |
| SCHEMBL12358671 | 0.74 | TRPV1 (0.43) | RAB9ASMN1; SMN2LMNANPC1PDE10A | |
| SCHEMBL12359117 | 0.73 | IDO1 (0.46) | RAB9ASMN1; SMN2NPC1MAPTPOLB | |
| SCHEMBL12653103 | 0.70 | MEN1 (0.57) | RAB9ASMN1; SMN2LMNANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | VRK1, VRK2, VIL1 | RAB9A 3985/4885SMN1; SMN2 4562/4885LMNA 4066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.