Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12358874 | 0.91 | TRPV1 (0.45) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12358835 | 0.85 | RAB9A (0.44) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12359134 | 0.83 | TRPV1 (0.45) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12358671 | 0.82 | TRPV1 (0.43) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1800423 | 0.79 | TRPV1 (0.67) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3764806 | 0.75 | MAPT (0.78) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12359233 | 0.75 | TRPV1 (0.57) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12359235 | 0.74 | TRPV1 (0.54) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2241134 | 0.73 | RAB9A (0.55) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8974000 | 0.72 | RAB9A (0.67) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | VRK1, VRK2, VIL1 | RAB9A 3985/4885NPC1 750/4885MAPT 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.