Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12358874 | 0.85 | TRPV1 (0.45) | TRPV1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL2241294 | 0.83 | TRPV1 (0.66) | TRPV1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL12359234 | 0.83 | RAB9A (0.53) | TRPV1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL12358671 | 0.79 | TRPV1 (0.43) | TRPV1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL12358835 | 0.76 | RAB9A (0.44) | TRPV1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL12359233 | 0.74 | TRPV1 (0.57) | TRPV1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL2238917 | 0.73 | TRPV1 (0.65) | TRPV1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL2242796 | 0.72 | TRPV1 (0.63) | TRPV1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL1794101 | 0.71 | TRPV1 (0.60) | TRPV1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL12359286 | 0.71 | TRPV1 (0.60) | TRPV1RAB9ATRPA1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | VRK1, VRK2, VIL1 | TRPV1 29/4885MAPT 4694/4885RAB9A 3985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.