Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 2/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.35 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11052652 | 0.82 | KDM4E (0.41) | KDM4EEPHX1ALDH1A1RAD52SMN1; SMN2 | |
| SCHEMBL11057051 | 0.81 | CYP1A2 (0.40) | KDM4EEPHX1ALDH1A1RAD52SMN1; SMN2 | |
| SCHEMBL28834995 | 0.80 | KDM4E (0.52) | KDM4EEPHX1TP53ANPEPERAP2 | |
| SCHEMBL10895092 | 0.80 | KDM4E (0.42) | KDM4EALDH1A1ANPEPERAP2RAD52 | |
| SCHEMBL7777018 | 0.79 | ALDH1A1 (0.52) | KDM4EEPHX1ALDH1A1ANPEPERAP2 | |
| SCHEMBL3679901 | 0.79 | ALDH1A1 (0.52) | KDM4EEPHX1ALDH1A1ANPEPERAP2 | |
| SCHEMBL20635257 | 0.79 | KDM4E (0.42) | KDM4EEPHX1ALDH1A1ANPEPERAP2 | |
| SCHEMBL11054753 | 0.78 | EPHX1 (0.39) | KDM4EEPHX1CXCR4CXCL12CYP1A2 | |
| SCHEMBL15108080 | 0.78 | KDM4E (0.48) | KDM4EEPHX1TP53ANPEPERAP2 | |
| SCHEMBL7776906 | 0.77 | ALDH1A1 (0.53) | KDM4EEPHX1ALDH1A1RAD52SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464373-A1 | METHOD FOR MODULATING THE PHARMACODYNAMIC EFFECT OF ORALLY ADMINISTERED GUANYLATE CYCLASE RECEPTOR AGONISTS | Ironwood Pharmaceuticals, Inc. (US) | 2012-06-20 | — | — | EP | claimed |
| WO-2011020054-A1 | METHOD FOR MODULATING THE PHARMACODYNAMIC EFFECT OF ORALLY ADMINISTERED GUANYLATE CYCLASE RECEPTOR AGONISTS | Ironwood Pharmaceuticals Inc. (US) | 2011-02-17 | — | — | WO | claimed |