Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.66 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.64 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17822214 | 0.92 | EPHX2 (0.75) | EPHX2KEAP1NFE2L2RAB9ATHRB | |
| SCHEMBL5483064 | 0.91 | EPHX2 (0.73) | EPHX2KEAP1NFE2L2RAB9ATHRB | |
| SCHEMBL9763664 | 0.91 | EPHX2 (0.73) | EPHX2KEAP1NFE2L2RAB9ATHRB | |
| SCHEMBL1235999 | 0.89 | THRB (0.68) | EPHX2KEAP1NFE2L2RAB9ATHRB | |
| SCHEMBL9809561 | 0.89 | RAB9A (0.76) | EPHX2KEAP1NFE2L2RAB9ATHRB | |
| SCHEMBL28274295 | 0.86 | EPHX2 (0.68) | EPHX2KEAP1NFE2L2RAB9ATHRB | |
| SCHEMBL25328235 | 0.85 | THRB (0.77) | EPHX2KEAP1NFE2L2RAB9ATHRB | |
| SCHEMBL16341081 | 0.85 | THRB (0.67) | EPHX2KEAP1NFE2L2RAB9ATHRB | |
| SCHEMBL2128698 | 0.85 | HDAC3 (0.68) | EPHX2KEAP1NFE2L2RAB9ATHRB | |
| SCHEMBL10897800 | 0.85 | EPHX2 (0.66) | EPHX2KEAP1NFE2L2RAB9ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285376-A1 | 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS | Chipscreen Biosciences Ltd. (CN) | 2011-02-23 | — | — | EP | disclosed |