Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | B3GNT2 | Q9NY97 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14566624 | 0.86 | LMNA (0.53) | LMNABRD4PGRMAOBPDE2A | |
| SCHEMBL9923035 | 0.77 | ADORA3 (0.56) | LMNABRD4MEN1KMT2AADORA3 | |
| SCHEMBL7220155 | 0.77 | DAO (0.66) | LMNABRD4PGRMAOBPDE2A | |
| SCHEMBL29859942 | 0.77 | LMNA (0.58) | LMNABRD4PGRMAOBPDE2A | |
| SCHEMBL2522765 | 0.77 | LMNA (0.58) | LMNABRD4PGRMAOBPDE2A | |
| SCHEMBL11548746 | 0.76 | PSMB8 (0.54) | LMNABRD4PGRPSMB8LRRK2 | |
| SCHEMBL27056782 | 0.76 | PSMB8 (0.51) | LMNABRD4PGRPSMB8LRRK2 | |
| SCHEMBL20772989 | 0.75 | BRD4 (0.49) | LMNABRD4PGRMAOBMEN1 | |
| SCHEMBL30832794 | 0.75 | BRD4 (0.49) | LMNABRD4PGRMAOBMEN1 | |
| SCHEMBL7220153 | 0.75 | LMNA (0.56) | LMNABRD4PGRPSMB8MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008326-B2 | 4-benzyledene-piperidin derivatives | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2011-08-30 | — | — | US | disclosed |
| US-8008326-B2 | 4-benzyledene-piperidin derivatives | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2011-08-30 | — | — | US | disclosed |
| US-20080312222-A1 | 4-Benzyledene-Piperidin Derivatives | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2008-12-18 | — | — | US | disclosed |
| US-20080312222-A1 | 4-Benzyledene-Piperidin Derivatives | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2008-12-18 | — | — | US | disclosed |
| WO-2007028445-A1 | 6-INDOLYL-4-YL-AMINO-5-HALOGENO-2-PYRIMIDINYL-AMINO DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312222-A1 | 4-Benzyledene-Piperidin Derivatives | GRIN2C, GRIN2A, GRIN1 | LMNA 4106/4885BRD4 413/4885PGR 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.