Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 9/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SLC18A1 | P54219 | 1/20 | 0.34 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311380 | 0.79 | NOS1 (0.61) | KDM4EGAAALDH1A1MEN1KMT2A | |
| SCHEMBL31389040 | 0.76 | PSMB8 (1.00) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL12716519 | 0.74 | PSMB8 (0.59) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL16150847 | 0.72 | PSMB8 (0.61) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL118671 | 0.72 | PSMB8 (1.00) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL13508892 | 0.71 | PSMB8 (0.61) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL779080 | 0.71 | PSMB8 (0.61) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL13508871 | 0.71 | PSMB8 (0.61) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL8701782 | 0.70 | PSMB8 (0.68) | PSMB8KEAP1KDM4EGAAALDH1A1 | |
| SCHEMBL14553955 | 0.69 | PSMB8 (0.70) | PSMB8KEAP1KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008326-B2 | 4-benzyledene-piperidin derivatives | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2011-08-30 | — | — | US | disclosed |
| US-8008326-B2 | 4-benzyledene-piperidin derivatives | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2011-08-30 | — | — | US | disclosed |
| US-20080312222-A1 | 4-Benzyledene-Piperidin Derivatives | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2008-12-18 | — | — | US | disclosed |
| US-20080312222-A1 | 4-Benzyledene-Piperidin Derivatives | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312222-A1 | 4-Benzyledene-Piperidin Derivatives | GRIN2C, GRIN2A, GRIN1 | PSMB8 470/4885KEAP1 2532/4885KDM4E 1054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.