Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12365262 | 0.91 | NAMPT (0.43) | NAMPTMRGPRX4PLAUMAPK14CYP11B1 | |
| SCHEMBL12389033 | 0.88 | NAMPT (0.43) | NAMPTMRGPRX4PLAUEGLN1CYP11B1 | |
| SCHEMBL12365091 | 0.88 | MRGPRX4 (0.42) | MRGPRX4EGLN1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL12365877 | 0.86 | NAMPT (0.43) | NAMPTMRGPRX4PLAUMAPK14CYP11B1 | |
| SCHEMBL12389598 | 0.86 | NAMPT (0.43) | NAMPTMRGPRX4PLAUCYP11B1CYP11B2 | |
| SCHEMBL12365024 | 0.85 | RARA (0.43) | NAMPTMRGPRX4PLAUEGLN2MAPK14 | |
| SCHEMBL12365333 | 0.85 | TDP1 (0.42) | MAPK14ALDH1A1ATMSMN1; SMN2NPSR1 | |
| SCHEMBL12365083 | 0.83 | MAPK14 (0.48) | MAPK14ALDH1A1SMN1; SMN2 | |
| SCHEMBL12365683 | 0.83 | BRD4 (0.39) | MAPK14ALDH1A1ATMSMN1; SMN2NPSR1 | |
| SCHEMBL12365044 | 0.83 | CA1 (0.42) | MAPK14ALDH1A1ATMSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | NAMPT 2562/4885MRGPRX4 2358/4885PLAU 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.