Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 5/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12365412 | 0.88 | SRD5A2 (0.43) | SRD5A2SRD5A1MAPK14ALDH1A1NOTUM | |
| SCHEMBL12365445 | 0.88 | ALDH1A1 (0.40) | SRD5A2SRD5A1MAPK14ALDH1A1NOTUM | |
| SCHEMBL12365389 | 0.86 | MAPK14 (0.45) | MAPK14ALDH1A1PTPRC | |
| SCHEMBL13384528 | 0.85 | ALDH1A1 (0.36) | MAPK14ALDH1A1GAALMNARAB9A | |
| SCHEMBL12365317 | 0.85 | SRD5A2 (0.51) | SRD5A2SRD5A1MAPK14ALDH1A1TTR | |
| SCHEMBL12365411 | 0.84 | MAPK14 (0.50) | SRD5A2SRD5A1MAPK14ALDH1A1TTR | |
| SCHEMBL12365414 | 0.84 | MAPK14 (0.45) | SRD5A2SRD5A1MAPK14ALDH1A1GRK6 | |
| SCHEMBL12365336 | 0.84 | ALDH1A1 (0.41) | SRD5A2SRD5A1MAPK14ALDH1A1GRK6 | |
| SCHEMBL12366787 | 0.83 | HTR2B (0.45) | — | |
| SCHEMBL12365839 | 0.83 | SRD5A2 (0.49) | SRD5A2SRD5A1MAPK14ALDH1A1GRK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | SRD5A2 412/4885SRD5A1 247/4885MAPK14 3304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.