Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11591975 | 0.86 | GAA (0.59) | HPGDKMT2ALMNACYP3A4HTT | |
| SCHEMBL12366121 | 0.83 | LMNA (0.64) | KMT2ALMNASMN1; SMN2MEN1GAA | |
| SCHEMBL13192876 | 0.83 | HPGD (0.62) | HPGDMAPK14KMT2ANPC1LMNA | |
| SCHEMBL13192880 | 0.80 | RNF4 (0.62) | HPGDMAPK14KMT2ANPC1LMNA | |
| SCHEMBL14944099 | 0.80 | MAPK14 (0.61) | HPGDMAPK14KMT2ANPC1LMNA | |
| SCHEMBL10133183 | 0.80 | NPC1 (0.75) | HPGDMAPK14KMT2ANPC1LMNA | |
| SCHEMBL1728537 | 0.79 | MAPK14 (0.68) | HPGDMAPK14KMT2ALMNACYP3A4 | |
| SCHEMBL18376355 | 0.79 | TSHR (0.59) | HPGDMAPK14KMT2ANPC1LMNA | |
| SCHEMBL12366146 | 0.78 | EPHX2 (0.53) | CYP3A4SMN1; SMN2HRH3EPHX2PPARG | |
| SCHEMBL22560078 | 0.78 | CYP3A4 (0.66) | HPGDMAPK14KMT2ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |