Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 14/20 | 0.51 |
| ▸ | NOS1 | P29475 | 14/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | NOS2 | P35228 | 9/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2262499 | 1.00 | NOS3 (0.51) | NOS3NOS1SLC6A2KCNH2CYP3A4 | |
| SCHEMBL2262503 | 1.00 | NOS3 (0.51) | NOS3NOS1SLC6A2KCNH2CYP3A4 | |
| SCHEMBL12367642 | 0.93 | NOS3 (0.59) | NOS3NOS1SLC6A2KCNH2CYP3A4 | |
| SCHEMBL14404485 | 0.90 | NOS3 (0.50) | NOS3NOS1SLC6A2KCNH2CYP3A4 | |
| SCHEMBL14404479 | 0.89 | NOS3 (0.53) | NOS3NOS1SLC6A2KCNH2CYP3A4 | |
| SCHEMBL12367335 | 0.88 | NOS3 (0.57) | NOS3NOS1SLC6A2KCNH2CYP3A4 | |
| SCHEMBL2261689 | 0.88 | NOS3 (0.57) | NOS3NOS1SLC6A2KCNH2CYP3A4 | |
| SCHEMBL4134299 | 0.85 | NOS3 (0.66) | NOS3NOS1SLC6A2KCNH2CYP3A4 | |
| SCHEMBL12367350 | 0.85 | NOS3 (0.46) | NOS3NOS1SLC6A2KCNH2CYP3A4 | |
| SCHEMBL1122042 | 0.85 | NOS3 (0.66) | NOS3NOS1SLC6A2KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010527-B1 | 1,5 AND 3,6- SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2013-08-14 | — | — | EP | disclosed |
| US-7989447-B2 | 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity | NEURAXON, INC. (CA) | 2011-08-02 | — | — | US | disclosed |
| US-7989447-B2 | 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity | NEURAXON, INC. (CA) | 2011-08-02 | — | — | US | disclosed |
| US-20070254940-A1 | 1,5 And 3,6- substituted indole compounds having NOS inhibitory activity | NEURAXON, INC. (CA) | 2007-11-01 | — | — | US | disclosed |
| US-20070254940-A1 | 1,5 And 3,6- substituted indole compounds having NOS inhibitory activity | NEURAXON, INC. (CA) | 2007-11-01 | — | — | US | disclosed |
| WO-2007118314-A1 | 1,5 AND 3,6- SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254940-A1 | 1,5 And 3,6- substituted indole compounds having NOS inhibitory activity | NOS1, NOS3, NOS2 | NOS3 2/4885NOS1 1/4885SLC6A2 1484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.