Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 4/20 | 0.47 |
| ▸ | HEXB | P07686 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | DHFR | P00374 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12368257 | 0.85 | HEXA (0.64) | HEXAHEXBMEN1KMT2ACYP1A2 | |
| SCHEMBL1885367 | 0.85 | HEXA (0.50) | HEXAHEXBMEN1KMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL1889973 | 0.83 | HEXA (0.49) | HEXAHEXBMEN1KMT2ACYP1A2 | |
| SCHEMBL11593238 | 0.81 | KMT2A (0.63) | HEXAHEXBMEN1KMT2ARAB9A | |
| SCHEMBL4526810 | 0.81 | HEXA (0.47) | HEXAHEXBMEN1KMT2ACYP1A2 | |
| SCHEMBL3500167 | 0.81 | DHFR (0.61) | HEXAHEXBKMT2ARAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL4537159 | 0.80 | HEXA (0.46) | HEXAHEXBMEN1KMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL4535303 | 0.80 | DHFR (0.42) | HEXAHEXBMEN1KMT2ACYP1A2 | |
| SCHEMBL14358933 | 0.79 | HEXA (0.65) | HEXAHEXBDHFRKDM4EHTT | |
| SCHEMBL12368256 | 0.77 | HEXA (0.73) | HEXAHEXBMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150272951-A1 | COMPOUNDS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES | HOSPITAL FOR SICK CHILDREN (CA) | 2015-10-01 | — | — | US | disclosed |
| US-20150272951-A1 | COMPOUNDS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES | HOSPITAL FOR SICK CHILDREN (CA) | 2015-10-01 | — | — | US | disclosed |
| US-20110195985-A1 | COMPOUNDS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES | THE HOSPITAL FOR SICK CHILDREN (CA) | 2011-08-11 | — | — | US | disclosed |
| US-20110195985-A1 | COMPOUNDS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES | THE HOSPITAL FOR SICK CHILDREN (CA) | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150272951-A1 | COMPOUNDS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES | GAA, GBA1, MAN2B1 | HEXA 48/4885HEXB 59/4885MEN1 2216/4885 |
| US-20110195985-A1 | COMPOUNDS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES | GAA, GBA1, MAN2B1 | HEXA 48/4885HEXB 59/4885MEN1 2216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.