Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 1/20 | 0.65 |
| ▸ | HEXB | P07686 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1885367 | 0.82 | HEXA (0.50) | HEXAHEXBALDH1A1CYP2D6MAPT | |
| SCHEMBL12368257 | 0.82 | HEXA (0.64) | HEXAHEXBALDH1A1CYP2D6DHFR | |
| SCHEMBL10778394 | 0.81 | HEXA (0.58) | HEXAHEXBALDH1A1CYP2D6ATM | |
| Hydrochloric Acid SCHEMBL1889973 | 0.80 | HEXA (0.49) | HEXAHEXBALDH1A1CYP2D6MAPT | |
| SCHEMBL12368248 | 0.79 | HEXA (1.00) | HEXAHEXBALDH1A1CYP2D6DHFR | |
| SCHEMBL11593238 | 0.79 | KMT2A (0.63) | HEXAHEXBALDH1A1CYP2D6ATM | |
| SCHEMBL12368258 | 0.79 | HEXA (0.47) | HEXAHEXBALDH1A1CYP2D6HTT | |
| SCHEMBL4526810 | 0.79 | HEXA (0.47) | HEXAHEXBALDH1A1CYP2D6DHFR | |
| SCHEMBL3500167 | 0.78 | DHFR (0.61) | HEXAHEXBALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL4537159 | 0.77 | HEXA (0.46) | HEXAHEXBALDH1A1CYP2D6DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2724156-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE | The Jackson Laboratory (US) | 2014-04-30 | — | — | EP | claimed |
| WO-2013003112-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE | THE JACKSON LABORATORY (US) | 2013-01-03 | — | — | WO | claimed |
| EP-2724156-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE | The Jackson Laboratory (US) | 2014-04-30 | — | — | EP | disclosed |
| WO-2013003112-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE | THE JACKSON LABORATORY (US) | 2013-01-03 | — | — | WO | disclosed |