Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HK1 | P19367 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591249 | 0.88 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10HPGDPRMT5 | |
| SCHEMBL1422093 | 0.84 | ALDH1A1 (0.55) | KDM4EALDH1A1HSD17B10HPGDPRMT5 | |
| SCHEMBL1598783 | 0.82 | ALDH1A1 (0.56) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL27544474 | 0.81 | TSHR (0.43) | KDM4EALDH1A1HSD17B10HPGDPRMT5 | |
| SCHEMBL21031894 | 0.80 | CACNA1B (0.46) | KDM4EALDH1A1HSD17B10HPGDPRMT5 | |
| SCHEMBL27645779 | 0.79 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B10HPGDPRMT5 | |
| SCHEMBL19506933 | 0.78 | PRMT5 (0.45) | KDM4EALDH1A1HSD17B10HPGDPRMT5 | |
| SCHEMBL12580665 | 0.76 | PRMT5 (0.44) | KDM4EALDH1A1HSD17B10HPGDPRMT5 | |
| SCHEMBL16234651 | 0.76 | HTR2C (0.55) | KDM4EALDH1A1HSD17B10HPGDPRMT5 | |
| SCHEMBL13640280 | 0.76 | ALDH1A1 (0.54) | KDM4EALDH1A1HSD17B10HPGDPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999119-B2 | Compounds having CRTH2 antagonist activity | OXAGEN LIMITED (GB) | 2011-08-16 | — | — | US | disclosed |
| US-20100035956-A1 | Compounds Having CRTH2 Antagonist Activity | OXAGEN LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035956-A1 | Compounds Having CRTH2 Antagonist Activity | HRH2, HRH1, HRH4 | KDM4E 4194/4885ALDH1A1 1293/4885HSD17B10 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.